
Cancer Detection
Cancer’s hiding place, exposed.
Delivering clarity, confidence, and peace of mind. iCAD’s ProFound Suite of cancer detection solutions are clinically proven to improve breast cancer detection and radiologist performance.

A screening revolution has arrived. The difference is ProFound.
Built with the latest in deep-learning, convolutional neural networks, iCAD’s ProFound AI cancer detection products offer high-performing, concurrent-read, cancer-detection and workflow solutions that rapidly and accurately analyzes each 2D or 3D mammogram image, detecting both malignant soft tissue densities and calcifications with unrivaled accuracy.

ProFound Detection V4
FDA Cleared
This next-generation AI solution, trained using advanced deep learning convolutional neural networks (CNN), offers advancements in cancer detection and specificity, achieving a 6.3% improved area under the receiver operating characteristic curve (AUC) over prior version, significantly improving the identification of hard-to-find and aggressive cancers while reducing false positives. This fourth-generation version introduces an option for clinicians to incorporate a prior exam into a current exam’s analysis.
Uncovers hidden cancers feared the most while reducing False Positives.
22%
improvement in finding hard-to-find cancers†
18%
improvement in cases with no marks†
Priors
incorporated into current AI analysis
† Compared to prior version 3.0.

ProFound AI® for Digital Breast Tomosynthesis and 2D Mammography.
DBT: FDA Cleared. CE Marked. Health Canada Licensed.
2D: CE Marked.
Expertly engineered to enhance cancer screening and diagnostics, augment radiologist performance, and improve patient lives, ProFound AI offers concurrent-read, cancer-detection, and workflow solutions that rapidly and accurately analyzes each tomosynthesis image, detecting both malignant soft tissue densities and calcifications with unrivaled accuracy.

SecondLook® Detection for 2D Mammography
Developed for 2D mammography, SecondLook’s Detection solution automatically marks suspicious lesions, identifying potential cancers and microcalcifications. The solution provides the radiologist with a “second look” which helps detect actionable missed cancers earlier than screening mammography alone, providing workflow enhancements and improved efficiency.

Early detection is critical!
When breast cancer is detected early and still localized, the 5-year relative survival rate is 99%,5 according to the American Cancer Society.
With AI, even earlier detection is possible!
When a mammogram uses ProFound Breast Health Suite, radiologists can identify potential cancers years earlier.1,2,17 Detecting cancer at the earliest possible localized stage, when treatments work best.
Find cancers earlier, with greater accuracy, and more efficiency.4
Clinical Confidence
Improve Cancer Detection Rates
Find Cancers Earlier for Better Outcomes
Reduce False Positives
Operational Efficiencies
Reduce Radiologist Reading Times
Improve AUC Performance
Fast Imaging Processing
Seamless Integrations & Secure Deployment
Competitive Differentiation
Market Current Technology
Enhance Patient Satisfaction
Align to Quality & Accreditation
Together, we can impact more lives.
We work the way you want to work.

Rapid implementation for a swift go-live.

Flexible & secure deployment options for smooth IT adoption.

Seamless integration within your workflow and systems you trust.

NEW ProFound Detection Version 4.0
Built for Her. Powered for You.
Next generation of Breast AI, engineered to support radiologists with powerful advancements in accuracy and precision.
New FDA Cleared ProFound Detection V4.0
Smarter Breast AI: Focus on the lesions that matter most.

Prior mammogram incorporated into AI algorithm.
Add a prior mammogram into the analysis of a current mammogram for even more precise results and fewer marks.

Ipsilateral Correlation of marked lesion improves results.
Comparing ipsilateral (CC-MLO) views of a lesion refines the score based on correlating matching and non-matching observations between views.

Find more cancers with fewer false positives.
V4 improves accuracy and precision, particularly for challenging cancer cases. Compared to ProFound AI Detection V3.

Schedule Upgrade to ProFound Detection V4
How the Algorithm works.
The ProFound AI algorithm is a highly accurate and clinically proven early cancer detection tool designed to be used concurrently while reading mammogram images. The algorithm has undergone extensive training using one of the most comprehensive 3D image datasets available.
Developed from:
- 20M+ million training images
- 88,000 training casess
- 13,500 biopsied cancers
- 130 contributing centers ensuring data diversity
A comprehensive ally to cancer detection:
Powered by deep-learning technology, the algorithm leverages convolutional neural networks for image processing and pattern recognition. It meticulously examines mammography slices to localize, segment, and classify areas that warrant attention. Suspicious structures, such as densities (masses, architectural distortions, and asymmetries), as well as clusters of calcifications, are pinpointed using a sophisticated contouring technique.

Example of ProFound Scorecard

Localized Lesion Marks and Overall Case Score.
A lesion mark outlines an area of concern (masses or calcifications) to be evaluated. Each lesion gets its own score, based on how similar the detection is to known cancerous lesions in the ProFound Detection training database.
Additionally, the whole exam is given a Case Score. This information is instrumental in helping radiologists manage their workload, make informed clinical decisions, and avoid burnout through streamlined workflows.
Scores represent a relative level of concern or suspicion and are not intended to be clinically used for the probability of cancer.
ProFound Interoperability.
Flexible deployment with unmatched speed, scalability, and security.
ProFound Cloud
Your
Cloud
ProFound
On-Premises
50+ PACS & 94 versions | 2D & 3D OEM manufacturers | AI platform providers & workflow systems
We work the way you want to work.

Rapid implementation for a swift go-live.

Flexible & secure deployment options for smooth IT adoption.

Seamless integration within your workflow and systems you trust.
expert voices
Joining forces against a common enemy.
In the fight against cancer, we’re stronger together. Learn why our customers believe that our solutions are the secret weapon for cancer detection and treatment.


Contact Us
Together, we can create a world where cancer can’t hide.
Ready to experience how ProFound can save lives?
3. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm. Accessed 1-20-23. FDA 510K submissions K182373 (iCAD), K201019 (Hologic) and K193229 (ScreenPoint). 4. Conant EF, Toledano AY, Periaswamy S, Fotin SV, Go J, Boatsman JE, Hoffmeister JW. Improving Accuracy and Efficiency with Concurrent Use of Artificial Intelligence for Digital Breast Tomosynthesis. Radiol Artif Intell. 2019 Jul 31;1(4):e180096. doi: 10.1148/ryai.2019180096. PMID: 32076660; PMCID: PMC6677281. 5. https://www.nationalbreastcancer.org/early-detection-of-breast-cancer. Accessed 11-01-2023.
iCAD data on file. Standalone performance varies by vendor.